Inheritance
Understandings:
• Mendel discovered the principles of inheritance with experiments in which large numbers of pea plants were crossed.
• Gametes are haploid so contain only one allele of each gene.
• The two alleles of each gene separate into different haploid daughter nuclei during meiosis.
• Fusion of gametes results in diploid zygotes with two alleles of each gene that may be the same allele or different alleles.
• Dominant alleles mask the effects of recessive alleles but co-dominant alleles have joint effects.
• Many genetic diseases in humans are due to recessive alleles of autosomal genes, although some genetic diseases are due to dominant or co-dominant alleles.
• Some genetic diseases are sex-linked. The pattern of inheritance is different with sex-linked genes due to their location on sex chromosomes.
• Many genetic diseases have been identified in humans but most are very rare.
• Radiation and mutagenic chemicals increase the mutation rate and can cause genetic diseases and cancer.
Theory of knowledge:
• Mendel’s theories were not accepted by the scientific community for a long time. What factors would encourage the acceptance of new ideas by the
scientific community?
• Aim 8: Social implications of diagnosis of mutations, including the effects on the family and stigmatization.
• Mendel discovered the principles of inheritance with experiments in which large numbers of pea plants were crossed.
• Gametes are haploid so contain only one allele of each gene.
• The two alleles of each gene separate into different haploid daughter nuclei during meiosis.
• Fusion of gametes results in diploid zygotes with two alleles of each gene that may be the same allele or different alleles.
• Dominant alleles mask the effects of recessive alleles but co-dominant alleles have joint effects.
• Many genetic diseases in humans are due to recessive alleles of autosomal genes, although some genetic diseases are due to dominant or co-dominant alleles.
• Some genetic diseases are sex-linked. The pattern of inheritance is different with sex-linked genes due to their location on sex chromosomes.
• Many genetic diseases have been identified in humans but most are very rare.
• Radiation and mutagenic chemicals increase the mutation rate and can cause genetic diseases and cancer.
Theory of knowledge:
• Mendel’s theories were not accepted by the scientific community for a long time. What factors would encourage the acceptance of new ideas by the
scientific community?
• Aim 8: Social implications of diagnosis of mutations, including the effects on the family and stigmatization.
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Applications and skills:
• Skill: Construction of Punnett grids for predicting the outcomes of monohybrid genetic crosses.
• Skill: Comparison of predicted and actual outcomes of genetic crosses using real data.
• Skill: Analysis of pedigree charts to deduce the pattern of inheritance of genetic diseases.
• Application: Red-green color blindness and hemophilia as examples of sex-linked inheritance.
• Skill: Construction of Punnett grids for predicting the outcomes of monohybrid genetic crosses.
• Skill: Comparison of predicted and actual outcomes of genetic crosses using real data.
• Skill: Analysis of pedigree charts to deduce the pattern of inheritance of genetic diseases.
• Application: Red-green color blindness and hemophilia as examples of sex-linked inheritance.
Watch video on blood clotting and hemophilia fundamentals.
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Application: Inheritance of cystic fibrosis and Huntington’s disease. Click below to learn how the mutation works to form cystic fibrosis.
Research the different case studies to see how it is treated.
Research the different case studies to see how it is treated.
Application: Inheritance of ABO blood groups.
The expected notation for ABO blood group alleles is:
Phenotype Genotype
A IAIA or IAi
B IBIB or IBi
AB IAIB
O ii
The expected notation for ABO blood group alleles is:
Phenotype Genotype
A IAIA or IAi
B IBIB or IBi
AB IAIB
O ii
Application: Consequences of radiation after nuclear bombing of Hiroshima and accident at Chernobyl. The year 2016 marks 70 years after Hiroshima was bombed August 6, 1945. There are multiple articles out about the victims and survivors. Chernobyl happened April 26, 1986.
Download the file, then answer questions on your own sheet. Turn in when complete!
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