Transcription and gene expression
Transcription is the synthesis of mRNA copied from the DNA base sequences by RNA polymerase.
Codons of three bases on mRNA correspond to one amino acid in a polypeptide.
Transcription occurs in a 5’ to 3’ direction.
RNA polymerase adds the 5´ end of the free RNA nucleotide to the 3´ end of the growing mRNA molecule.
Codons of three bases on mRNA correspond to one amino acid in a polypeptide.
Transcription occurs in a 5’ to 3’ direction.
RNA polymerase adds the 5´ end of the free RNA nucleotide to the 3´ end of the growing mRNA molecule.
Understandings:
Eukaryotic cells modify mRNA after transcription.
Gene expression is regulated by proteins that bind to specific base sequences in DNA.
The environment of a cell and of an organism has an impact on gene expression.
Eukaryotic cells modify mRNA after transcription.
Gene expression is regulated by proteins that bind to specific base sequences in DNA.
The environment of a cell and of an organism has an impact on gene expression.
Nucleosomes help to regulate transcription in eukaryotes.
Skill: Analysis of changes in the DNA methylation patterns.
DNA coiling around proteins, called histones, to form chromatin.
Skill: Utilization of molecular visualization software to analyse the association between protein and DNA within a nucleosome.
Skill: Analysis of changes in the DNA methylation patterns.
DNA coiling around proteins, called histones, to form chromatin.
Skill: Utilization of molecular visualization software to analyse the association between protein and DNA within a nucleosome.
Application: The promoter as an example of non-coding DNA with a function. This is the region where RNA polymerase attaches and includes the TATA box.